About: Recombinant Interferon Gamma

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Attributes	Values
rdf:type	Class
rdfs:label	Recombinant Interferon Gamma
equivalentClass	nodeID://b640572
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Recombinant Interferon Gamma
NSC_Code	600662 635256
UMLS_CUI	C0021740
CAS_Registry	82115-62-6
Accepted_Therapeutic_Use_For	Chronic granulomatous disease; Osteopetrosis
In_Clinical_Trial_For	Idiopathic pulmonary fibrosis
ALT_DEFINITION	activates NK cells, cytotoxic T cells, endothelial cells, and macrophages; stimulates LAK activity; costimulates B cell proliferation; inhibits T cell proliferation; implicated in aberrant expression of MHC II antigens leading to autoimmune disease.CSP2002 The major interferon produced by mitogenically or antigenically stimulated lymphocytes. It is structurally different from type I interferon (INTERFERON TYPE I) and its major activity is immunoregulation. It has been implicated in the expression of class II histocompatibility antigens in cells that do not normally produce them, leading to autoimmune disease.MSH2002_06_01
PDQ_Open_Trial_Search_ID	40469
PDQ_Closed_Trial_Search_ID	40469
Legacy_Concept_Name	Therapeutic_Interferon_Gamma
FULL_SYN	GinterferonSYNCI Gamma-InterferonSYNCI Gamma Interferon (GEN)SYNCI Interferon Gamma (BIO)SYNCI IFN-gABNCI Interferon, GammaSYNCI Recombinant Interferon GammaPTNCI Interferon GammaSYDTPNSC0635256 Gamma Interferon-SCHSYNCI
DEFINITION	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04)NCI
code	C583
is rdfs:subClassOf of	Interferon Gamma-1a Interferon Gamma-1b
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