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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Imipenem
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Imipenem
NSC_Code
  • 717864
UMLS_CUI
  • C0020933
CAS_Registry
  • 74431-23-5
FDA_UNII_Code
  • 71OTZ9ZE0A
Contributing_Source
  • FDA
ALT_DEFINITION
  • An antibiotic drug used to treat severe or very resistant infection. It belongs to the family of drugs called carbapenems.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42116
PDQ_Closed_Trial_Search_ID
  • 42116
Chemical_Formula
  • C12H17N3O4S.H2O
Legacy_Concept_Name
  • Imipenem
CHEBI_ID
  • CHEBI:51799
FULL_SYN
  • IMIPENEMPTFDA71OTZ9ZE0A
  • ImipenemSYDTPNSC0717864
  • MK-0787CNNCI
  • imipenemPTNCI-GLOSSCDR0000045422
  • ImipenemPTNCI
  • ImipemideSYNCI
DEFINITION
  • A broad-spectrum, semi-synthetic beta-lactam carbapenem derived from thienamycin, produced by Streptomyces cattleya. Imipenem binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes that are involved in the last stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. This inactivation results in the weakening of the bacterial cell wall and eventually causes cell lysis. Imipenem has the greatest affinity for PBP 1A, 1B, and 2, and its lethal effect is related to binding to PBP 2 and 1B. This antibiotic is active against a wide range of gram-positive and gram-negative organisms and is stable in the presence of beta-lactamases. (NCI05)NCI
code
  • C570
sameAs
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