About: Hydroxychloroquine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Hydroxychloroquine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Hydroxychloroquine
UMLS_CUI
  • C0020336
CAS_Registry
  • 118-42-3
Accepted_Therapeutic_Use_For
  • Malaria; Rheumatoid arthritis
In_Clinical_Trial_For
  • Graft versus host disease
FDA_UNII_Code
  • 4QWG6N8QKH
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that decreases immune responses in the body. It is used to treat some autoimmune diseases, and is being studied as a treatment for graft-versus-host disease. Hydroxychloroquine belongs to the family of drugs called antiprotozoals.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38571
PDQ_Closed_Trial_Search_ID
  • 38571
Chemical_Formula
  • C18H26ClN3O
Legacy_Concept_Name
  • Hydroxychloroquine
FULL_SYN
  • hydroxychloroquinePTNCI-GLOSSCDR0000045084
  • HydroxychloroquinePTNCI
  • HYDROXYCHLOROQUINEPTFDA4QWG6N8QKH
DEFINITION
  • A 4-aminoquinoline with immunosuppressive, antiautophagy, and antimalarial activities. Although the precise mechanism of action is unknown, hydroxychloroquine may suppress immune function by interfering with the processing and presentation of antigens and the production of cytokines. As a lysosomotropic agent, hydroxychloroquine raises intralysosomal pH, impairing autophagic protein degradation; hydroxychloroquine-mediated accumulation of ineffective autophagosomes may result in cell death in tumor cells reliant on autophagy for survival. In addition, this agent is highly active against the erythrocytic forms of P. vivax and malariae and most strains of P. falciparum but not the gametocytes of P. falciparum.NCI
code
  • C557
sameAs
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