About: Saponin-Cholesterol-Phospholipid Adjuvant     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Saponin-Cholesterol-Phospholipid Adjuvant
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Saponin-Cholesterol-Phospholipid Adjuvant
UMLS_CUI
  • C1529741
PDQ_Open_Trial_Search_ID
  • 465382
PDQ_Closed_Trial_Search_ID
  • 465382
Legacy_Concept_Name
  • Saponin_Cholesterol_Phospholipid_Adjuvant
FULL_SYN
  • Saponin-Cholesterol-Phospholipid AdjuvantPTNCI
  • IscomatrixBRNCI
DEFINITION
  • An adjuvant comprised of saponin, derived from the bark of Quillaia saponaria Molina, cholesterol and phospholipid with antigen-delivery and immunostimulatory activities. This saponin-based adjuvant in combination with various antigens, including those for human papilloma virus (HPV), hepatitis C virus (HCV), and the human cancer antigen NY-ESO-1, may result in potent antibody, CD4+ T-helper-cell, and CD8+ cytotoxic T-cell responses against the targeted antigen. In addition, this agent may reduce the amount of antigen necessary to induce an efficient immune response in the host.NCI
code
  • C53436
http://linked.open...y/mesh/hasConcept
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