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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Diindolylmethane
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Diindolylmethane
UMLS_CUI
  • C1100708
CAS_Registry
  • 1968-05-4
ALT_DEFINITION
  • A substance being studied in the treatment of prostate cancer and in the prevention of cervical cancer. Diindolylmethane is found in cruciferous vegetables like broccoli, brussels sprouts, cauliflower, cabbage, and kale. It is a type of plant indole.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 462587
PDQ_Closed_Trial_Search_ID
  • 462587
Legacy_Concept_Name
  • Diindolylmethane
CHEBI_ID
  • CHEBI:50182
FULL_SYN
  • DIMPTNCI-GLOSSCDR0000523294
  • 3,3'-Methylenebis-1H-indolePTDCP05123
  • 3,3'-Methylenebis-1H-indoleSNNCI
  • DiindolylmethanePTNCI
  • Di-Indoly MethaneSYNCI
  • DIMPROBRNCI
  • DIM-PlusBRNCI
  • 3,3'-DiindolymethaneSNNCI
  • CCRIS 5806CNNCI
  • diindolylmethanePTNCI-GLOSSCDR0000489306
DEFINITION
  • A phytonutrient and plant indole found in cruciferous vegetables including broccoli, Brussels sprouts, cabbage, cauliflower and kale, with potential anti-androgenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown.NCI
code
  • C53434
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