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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • ADH-1
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • ADH-1
UMLS_CUI
  • C1706644
PDQ_Open_Trial_Search_ID
  • 462569
PDQ_Closed_Trial_Search_ID
  • 462569
Legacy_Concept_Name
  • ADH-1
FULL_SYN
  • ADH-1PTNCI
  • ExherinBRNCI
DEFINITION
  • A small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis. N-cadherin, a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins involved in calcium-mediated cell-cell adhesion and signaling mechanisms; may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels.NCI
code
  • C53399
http://linked.open...y/mesh/hasConcept
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