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AttributesValues
rdf:type
rdfs:label
  • Codeine Sulfate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Codeine Sulfate
UMLS_CUI
  • C0304352
CAS_Registry
  • 6854-40-6
FDA_UNII_Code
  • 11QV9BS0CB
Contributing_Source
  • FDA
Chemical_Formula
  • 2C18H21NO3.3H2O.H2SO4
Legacy_Concept_Name
  • Codeine_Sulfate
FULL_SYN
  • 7,8-Didehydro-4,5-epoxy- 3-methoxy-17-methyl-(5a ,6a)-Morphinan-6-ol Sulfate (2:1)SNNCI
  • CODEINE SULFATEPTFDA11QV9BS0CB
  • Codeine SulfatePTNCI
  • Codeine, sulfateSYDTPNSC0011427
DEFINITION
  • The sulfate salt form of codeine, a naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activity. Codeine sulfate mimics the actions of opioids by binding to the opioid receptors at many sites within the central nervous system (CNS). Stimulation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This results in a decrease in intracellular cAMP and leads to a reduction in the release of neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline. The analgesic effect of codeine sulfate is likely due to its metabolite morphine, which induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby resulting in hyperpolarization and reduced neuronal excitability.NCI
code
  • C53137
sameAs
is Has_Salt_Form of
is sameAs of
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