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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Gossypol
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Gossypol
NSC_Code
  • 56817
  • 624336
UMLS_CUI
  • C0018096
CAS_Registry
  • 303-45-7
FDA_UNII_Code
  • KAV15B369O
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of several types of cancer. It comes from the seed of the cotton plant (Gossypium). It blocks the growth of cells and may kill cancer cells. Cottonseed meal toxin may also act as a male contraceptive (a type of birth control).NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 505287
PDQ_Closed_Trial_Search_ID
  • 505287
Chemical_Formula
  • C30H30O8
Legacy_Concept_Name
  • Gossypol
CHEBI_ID
  • CHEBI:28584
FULL_SYN
  • (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6'7, 7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-SYDTPNSC0056817
  • (+/-)-GossypolSYNCI
  • 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)[2,2'-binaphthalene]-8,8'-dicarboxaldehydeSNNCI
  • 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3-3'-dimethyl[2,2'-binaphthalene]-8,8'-dicarboxaldehydeSNNCI
  • GOSSYPOLPTFDAKAV15B369O
  • GOSSYPOLSYDTPNSC0056817
  • BL-193CNNCI
  • Tash 1BRNCI
  • 2,2'-bis[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene]SNNCI
  • cottonseed meal toxinPTNCI-GLOSSCDR0000644312
  • PogosinSYNCI
  • 2,2'-bis[1,6,7-Trihydroxy-4-methyl-5-isopropyl-8-aldehydonaphthaleneSNNCI
  • GossypolPTNCI
  • gossypolPTNCI-GLOSSCDR0000045428
  • No FertilBRNCI
  • Cottonseed Meal ToxinSYNCI
  • GossypolPTDCP30243
DEFINITION
  • An orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cell cycle arrest at the G0/G1 phase, thereby inhibiting DNA replication and inducing apoptosis. This agent also inhibits cell-signaling enzymes, resulting in inhibition of cell growth, and may act as a male contraceptive.NCI
code
  • C529
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