About: Ganglioside GM2     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ganglioside GM2
rdfs:subClassOf
Semantic_Type
  • Lipid
  • Immunologic Factor
Preferred_Name
  • Ganglioside GM2
UMLS_CUI
  • C0016896
CAS_Registry
  • 19600-01-2
PDQ_Open_Trial_Search_ID
  • 40785
PDQ_Closed_Trial_Search_ID
  • 40785
Legacy_Concept_Name
  • Ganglioside_GM2
FULL_SYN
  • Ganglioside GM2PTNCI
  • GM2 gangliosideSYNCI
DEFINITION
  • A glycosphingolipid antigen expressed by a variety of human cancer cells. GM2 containing vaccines have been shown to elicit antibodies production in melanoma patients without deleterious effects associated with an immune response to GM2. Mutations in at least 1 of 3 recessive genes: HEXA, HEXB, and GM2A cause defects in GM2 catabolism, leading to lysosomal lipid storage disorders that manifest primarily as neurodegenerative diseases, including Tay-Sachs and Sandhoff Disease.NCI
code
  • C516
sameAs
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