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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tegafur
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Tegafur
NSC_Code
  • 148958
UMLS_CUI
  • C0016778
CAS_Registry
  • 17902-23-7
FDA_UNII_Code
  • 1548R74NSZ
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that belongs to the family of drugs called antimetabolites.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39248
PDQ_Closed_Trial_Search_ID
  • 39248
Chemical_Formula
  • C8H9FN2O3
Legacy_Concept_Name
  • Tegafur
FULL_SYN
  • FTABNCI
  • TEGAFURPTFDA1548R74NSZ
  • TegafurSYDTPNSC0148958
  • RiolFBNCI
  • 5-Fluoro-1-(tetrahydro-2-furyl)-uracilSNNCI
  • LamarFBNCI
  • FT-207CNNCI
  • FulaidFBNCI
  • NeberkFBNCI
  • FentalFBNCI
  • LifrilFBNCI
  • ExonalFBNCI
  • FtoralFBNCI
  • UtefosFBNCI
  • tegafurPTNCI-GLOSSCDR0000045201
  • FulfeelFBNCI
  • TefsielFBNCI
  • TegafurPTNCI
  • CitofurFBNCI
  • FtorafurPTNCI-GLOSSCDR0000549432
  • 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedioneSNNCI
  • TegafurPTDCP00543
  • FlorafurBRNCI
  • FtoralonFBNCI
  • FtorafurFBNCI
  • FutrafulFBNCI
  • SunfuralFBNCI
  • WR-220066CNNCI
  • MJF-12264CNNCI
  • NitobanilFBNCI
  • CoparoginFBNCI
  • FurafluorFBNCI
  • 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4-(1H,3H)-pyrimidinedioneSNNCI
  • FluorofurBRNCI
  • N1-(2'-Furanidyl)-5-fluorouracilSNNCI
  • Uracil, 5-fluoro-1-(tetrahydro-2-furyl)-SYDTPNSC0148958
  • FurofutranFBNCI
  • SinoflurolFBNCI
DEFINITION
  • A congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by inhibiting thymidylate synthase and reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate. (NCI04)NCI
code
  • C513
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