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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Flutamide
equivalentClass
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Flutamide
NSC_Code
  • 147834
  • 215876
UMLS_CUI
  • C0016384
CAS_Registry
  • 13311-84-7
Accepted_Therapeutic_Use_For
  • Hirsutism; Prostate carcinoma
In_Clinical_Trial_For
  • Congenital adrenal hyperplasia; Prostate cancer
FDA_UNII_Code
  • 76W6J0943E
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that is a type of antiandrogen.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39811
PDQ_Closed_Trial_Search_ID
  • 39811
Chemical_Formula
  • C11H11F3N2O3
Legacy_Concept_Name
  • Flutamide
CHEBI_ID
  • CHEBI:5132
FULL_SYN
  • 4'-Nitro-3'-trifluoromethylisobutyranilideSNNCI
  • FlutamidePTDCP01895
  • ProstadirexFBNCI
  • ProstogenatFBNCI
  • Alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidideSNNCI
  • FLUTABNCI
  • 4'-Nitro-3'-trifluoromethylisobutyranilideSYDTPNSC0215876
  • 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamideSNNCI
  • Sch 13521SYDTPNSC0215876
  • FLUTAMIDEPTFDA76W6J0943E
  • ApimidFBNCI
  • ChimaxFBNCI
  • FlukenFBNCI
  • FlulemFBNCI
  • EuflexFBNCI
  • FlutanFBNCI
  • TafenilFBNCI
  • FugerelFBNCI
  • OncosalFBNCI
  • EulexinBRNCI
  • FlutacanFBNCI
  • ProfamidFBNCI
  • DrogenilFBNCI
  • FlugerelSYNCI
  • EulexineFBNCI
  • FlutaminFBNCI
  • NiftolidSYNCI
  • GrisetinFBNCI
  • FlutamexFBNCI
  • FlucinomSYNCI
  • ProsticaFBNCI
  • SCH 13521CNNCI
  • Fluta-GryFBNCI
  • FlutabeneFBNCI
  • FlucinomeFBNCI
  • FlutamidePTNCI
  • TecnoflutFBNCI
  • FlutaplexFBNCI
  • TestotardFBNCI
  • ProstacurFBNCI
  • flutamidePTNCI-GLOSSCDR0000045264
DEFINITION
  • A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04)NCI
code
  • C509
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