About: Floxuridine

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Floxuridine
rdfs:subClassOf	Pyrimidine Antagonist
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name	Floxuridine
NSC_Code	27640
UMLS_CUI	C0947603
CAS_Registry	50-91-9
Accepted_Therapeutic_Use_For	Gastrointestinal adenocarcinoma metastatic to the liver
In_Clinical_Trial_For	Colorectal cancer; Gastric cancer
FDA_UNII_Code	039LU44I5M
Contributing_Source	FDA
ALT_DEFINITION	A drug used in the treatment of cancer. It is a type of antimetabolite.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39242
PDQ_Closed_Trial_Search_ID	39242
Chemical_Formula	C9H11FN2O5
Legacy_Concept_Name	Floxuridine
CHEBI_ID	CHEBI:60761
FULL_SYN	FluorodeoxyuridineSYDTPNSC0027640 FUDRSYDTPNSC0027640 2'-Deoxy-5-fluorouridinePTDCP07814 FloxuridinePTNCI 2-Deoxy-5-fluorouridineSNNCI 2'-Deoxy-5-fluorouridineSNNCI 5-Fluoro-2'-deoxyuridineSNNCI 5-FUDRSYDTPNSC0027640 floxuridinePTNCI-GLOSSCDR0000045198 5-FluorodeoxyuridineSYDTPNSC0027640 Fluoruridine DeoxyriboseSYNCI Fluorouridine DeoxyriboseSYNCI 5-Fluorouracil deoxyribosideSYDTPNSC0027640 FDURABNCI 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracilSNNCI FUdRABNCI 5-Fluorouridine DeoxyriboseSNNCI 5-FUdRABNCI 5-Fluorouracil DeoxyribosideSNNCI FluorodeoxyuridineSYNCI 2'-Deoxy-5-fluorouridineSYDTPNSC0027640 5-Fluoro-2'-deoxyuridineSYDTPNSC0027640 5-Fluoro-2'-deoxy-beta-uridineSNNCI WR-138720CNNCI Fluoruridine deoxyriboseSYDTPNSC0027640 5-FluorodeoxyuridineSNNCI FloxuridinSYDTPNSC0027640 FLOXURIDINEPTFDA039LU44I5M FloxuridinSYNCI
DEFINITION	A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)NCI
code	C504
sameAs	Floxuridine
is someValuesFrom of	nodeID://b656767 nodeID://b657143 nodeID://b659908 nodeID://b660008 nodeID://b660270 nodeID://b660272 nodeID://b660276 nodeID://b666513 nodeID://b666514 nodeID://b666518 nodeID://b666522 nodeID://b666524 nodeID://b667441 nodeID://b667445 nodeID://b673689 nodeID://b673691 nodeID://b673695 nodeID://b673700 nodeID://b673703 nodeID://b673704 nodeID://b673708 nodeID://b673709 nodeID://b673713 nodeID://b673715 nodeID://b673717 nodeID://b673721 nodeID://b673724 nodeID://b673726 nodeID://b673727 nodeID://b673731
is sameAs of	Floxuridine

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