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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Alvimopan
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Alvimopan
UMLS_CUI
  • C1508750
CAS_Registry
  • 170098-38-1
FDA_UNII_Code
  • 677C126AET
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 453551
PDQ_Closed_Trial_Search_ID
  • 453551
Chemical_Formula
  • C25H32N2O4.2H2O
Legacy_Concept_Name
  • Alvimopan
FULL_SYN
  • ALVIMOPANPTFDA677C126AET
  • EnteregBRNCI
  • LY-246376CNNCI
  • ADL8-2698CNNCI
  • AlvimopanPTNCI
DEFINITION
  • A synthetic trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone.NCI
code
  • C49096
sameAs
http://linked.open...y/mesh/hasConcept
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