About: Retrovector Encoding Mutant Anti-Cyclin G1     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Retrovector Encoding Mutant Anti-Cyclin G1
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Retrovector Encoding Mutant Anti-Cyclin G1
UMLS_CUI
  • C1709935
PDQ_Open_Trial_Search_ID
  • 446577
PDQ_Closed_Trial_Search_ID
  • 446577
Legacy_Concept_Name
  • Retrovector_Encoding_Anti-Cyclin_G
FULL_SYN
  • REXIN-GBRNCI
  • Mx-dnG1SYNCI
  • Retrovector Encoding Mutant Anti-Cyclin G1PTNCI
DEFINITION
  • A replication-incompetent, pathotropic, tumor matrix (collagen)-targeted, retroviral vector encoding an N-terminal deletion mutant form of the cyclin G1 gene with potential antineoplastic activity. Under the control of a hybrid long-terminal repeat/cytomegalovirus (CMV) promoter, retrovector encoding mutant anti-cyclin G expresses the mutant cyclin G1 construct, resulting in disruption of tumor cell cyclin G1 activity and decreased cellular proliferation and angiogenesis. This agent preferentially targets collagen of the tumor matrix because of the incorporation of the collagen-binding domain of von Willebrand factor (vWF) on the retrovector surface. Exploiting the collagen-targeting mechanism of vWF permits delivery of the retrovector to tumor sites where angiogenesis and collagen matrix exposure occur.NCI
code
  • C49082
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