About: Ridaforolimus     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ridaforolimus
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ridaforolimus
UMLS_CUI
  • C2713007
CAS_Registry
  • 572924-54-0
FDA_UNII_Code
  • 48Z35KB15K
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of soft tissue and bone cancers. It is also being studied in the treatment of other solid tumors and hematologic cancer. Ridaforolimus stops cells from dividing and may cause cancer cells to die. It is a type of mTOR inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 354223
PDQ_Closed_Trial_Search_ID
  • 354223
Chemical_Formula
  • C53H84NO14P
Legacy_Concept_Name
  • AP23573
FULL_SYN
  • DeforolimusSYNCI
  • RIDAFOROLIMUSPTFDA48Z35KB15K
  • RidaforolimusPTNCI
  • Rapamycin, 42-(dimethylphosphinate)SYNCI
  • AP23573PTNCI-GLOSSCDR0000446800
  • ridaforolimusPTNCI-GLOSSCDR0000642130
  • AP23573CNNCI
  • MK-8669CNNCI
DEFINITION
  • A small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR), which may result in cell cycle arrest and, consequently, the inhibition of tumor cell growth and proliferation. Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K/Akt signaling pathway.NCI
code
  • C49061
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