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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ropidoxuridine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Ropidoxuridine
NSC_Code
  • 726188
UMLS_CUI
  • C0088688
CAS_Registry
  • 93265-81-7
FDA_UNII_Code
  • 3HX21A3SQF
Contributing_Source
  • FDA
Chemical_Formula
  • C9H11IN2O4
Legacy_Concept_Name
  • _5-Iodo-2-Pyrimidinone-2-Deoxyribose
FULL_SYN
  • RopidoxuridinePTNCI
  • 2(1H)-Pyrimidinone, 1-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-5-iodo-SNNCI
  • ROPIDOXURIDINEPTFDA3HX21A3SQF
  • RopidoxuridineSYNCI
  • 5-Iodo-2-pyrimidinone-2'-deoxyriboseSNNCI
  • IPdRSYNCI
DEFINITION
  • An orally available thymidine analogue and prodrug of 5-iododeoxyuridine (IUdR), an iodinated analogue of deoxyuridine, with radiosensitizing activity. Ropidoxuridine is efficiently converted to IUdR by a hepatic aldehyde oxidase. IUdR is incorporated into DNA during replication and sensitizing cells to ionizing radiation by increasing DNA strand breaks. Compared to IUdR, ropidoxuridine is associated with a lower toxicity profile and improved anti-tumor activity.NCI
code
  • C48813
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