About: Amifostine

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Amifostine
rdfs:subClassOf	Cytoprotective Agent
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Organophosphorus Compound
Preferred_Name	Amifostine
NSC_Code	296961
UMLS_CUI	C0591467
CAS_Registry	112901-68-5
Accepted_Therapeutic_Use_For	Cisplatin-induced nephrotoxicity; Radiation-induced mucositis and xerostomia
In_Clinical_Trial_For	Acute myeloid leukemia; Amyloidosis, primary systemic; Bladder cancer; Head and Neck cancer; Liver cancer; Non-small cell lung cancer; Prostatic neoplasms; Small cell lung cancer; Unspecified solid tumor
FDA_UNII_Code	M487QF2F4V
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	39741
PDQ_Closed_Trial_Search_ID	39741
Chemical_Formula	C5H15N2O3PS.3H2O
Legacy_Concept_Name	Amifostine
FULL_SYN	Aminopropylaminoethylthiophosphoric Acid TrihydrateSYNCI S-(N-(3-Aminopropyl)-2-aminoethyl)thiophosphoric Acid TrihydrateSNNCI WR 2721SYDTPNSC0296961 2-[(3-Aminopropyl)amino]ethanethiol Dihydrogen Phosphate Ester TrihydrateSNNCI WR2721CNNCI APAETPABNCI EthyolBRNCI WR-2721CNNCI CytofosFBNCI GammaphosSYDTPNSC0296961 AMIFOSTINEPTFDAM487QF2F4V YM-08310CNNCI EthiofosSYNCI AmifostineSYDTPNSC0296961 GammaphosSYNCI S-2-(3-Aminopropylamino)ethylphosphorothioic Acid TrihydrateSNNCI Amifostine TrihydrateSYNCI AmifostinePTNCI
DEFINITION	The trihydrate form of a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues.NCI
code	C488
sameAs	Amifostine
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0432472
is someValuesFrom of	nodeID://b645244 nodeID://b645248 nodeID://b645251 nodeID://b645255 nodeID://b645257 nodeID://b645261 nodeID://b645264 nodeID://b645268 nodeID://b645271 nodeID://b645274 nodeID://b645280 nodeID://b645282 nodeID://b645288 nodeID://b645291 nodeID://b645295 nodeID://b645298 nodeID://b645301 nodeID://b645306 nodeID://b645308 nodeID://b645312 nodeID://b645313 nodeID://b645316 nodeID://b645322 nodeID://b645324 nodeID://b645328 nodeID://b645329 nodeID://b645332 nodeID://b645335 nodeID://b645337 nodeID://b645344 nodeID://b645347 nodeID://b645349 nodeID://b645352 nodeID://b645354 nodeID://b645356 nodeID://b645358 nodeID://b645361 nodeID://b645362 nodeID://b645365 nodeID://b645366 nodeID://b645368 nodeID://b645371
is sameAs of	Amifostine

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