About: Taxane Analogue TPI 287     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Taxane Analogue TPI 287
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Taxane Analogue TPI 287
UMLS_CUI
  • C1710314
CAS_Registry
  • 849213-15-6
PDQ_Open_Trial_Search_ID
  • 438803
PDQ_Closed_Trial_Search_ID
  • 438803
Legacy_Concept_Name
  • TPI_287
FULL_SYN
  • Taxane Analogue TPI 287PTNCI
  • TPI 287CNNCI
DEFINITION
  • A synthetic, third generation taxane with potential antineoplastic activity. TPI 287 binds to tubulin and stabilizes microtubules, resulting in inhibition of microtubule assembly/disassembly dynamics, cell cycle arrest at the G2/M phase, and apoptosis.NCI
code
  • C48424
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