About: SB-AS15 Adjuvant     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • SB-AS15 Adjuvant
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • SB-AS15 Adjuvant
UMLS_CUI
  • C1541296
PDQ_Open_Trial_Search_ID
  • 373865
PDQ_Closed_Trial_Search_ID
  • 373865
Legacy_Concept_Name
  • SB-AS15_Adjuvant
FULL_SYN
  • SB-AS15 AdjuvantPTNCI
  • SB AS15SYNCI
DEFINITION
  • A vaccine adjuvant containing CpG 7909, monophosphoryl lipid, and QS-21 with potential antineoplastic and immunostimulatory activities. CpG 7909 is a synthetic 24-mer oligonucleotide containing 3 CpG motifs that selectively targets Toll-like receptor 9 (TLR9), thereby activating dendritic and B cells and stimulating cytotoxic T cell and antibody responses against tumor cells bearing tumor antigens. Monophosphoryl lipid is a detoxified derivative of lipid A, a component of Salmonella minnesota lipopolysaccharide (LPS); this agent may enhance humoral and cellular responses to various antigens. QS-21 is a purified, naturally occurring saponin derived from the South American tree Quillaja saponaria Molina and exhibits various immunostimulatory activities. Combinations of monophosphoryl lipid and QS-21 may be synergistic in inducing humoral and cellular immune responses. (NCI05)NCI
code
  • C48421
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