About: Saracatinib     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Saracatinib
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Saracatinib
NSC_Code
  • 735464
UMLS_CUI
  • C1706679
CAS_Registry
  • 379231-04-6
FDA_UNII_Code
  • 9KD24QGH76
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of some types of cancer. AZD0530 blocks enzymes needed for cancer growth. It is a type of tyrosine kinase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 453588
PDQ_Closed_Trial_Search_ID
  • 453588
Chemical_Formula
  • C27H32ClN5O5
Legacy_Concept_Name
  • AZD0530
FULL_SYN
  • SaracatinibPTNCI
  • 4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-SNNCI
  • N-(5-Chloro-1,3-Benzodioxol-4-Yl)-7-(2-(4-Methylpiperazin-1-yl)Ethoxy)-5-((Oxan-4-yl)Oxy)Quinazolin-4-AmineSNNCI
  • AZD0530PTNCI-GLOSSCDR0000532132
  • SRC Kinase Inhibitor AZD0530SYNCI
  • AZD0530CNNCI
  • SARACATINIBPTFDA9KD24QGH76
DEFINITION
  • An orally available 5-, 7-substituted anilinoquinazoline with anti-invasive and anti-tumor activities. Saracatinib is a dual-specific inhibitor of Src and Abl, protein tyrosine kinases that are overexpressed in chronic myeloid leukemia cells. This agent binds to and inhibits these tyrosine kinases and affects cell motility, cell migration, adhesion, invasion, proliferation, differentiation, and survival. Specifically, Saracatinib inhibits Src kinase-mediated osteoclast bone resorption.NCI
code
  • C48378
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