About: Hydrocortisone Probutate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Hydrocortisone Probutate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Hydrocortisone Probutate
UMLS_CUI
  • C0063076
CAS_Registry
  • 72590-77-3
FDA_UNII_Code
  • O6550D6K3A
Contributing_Source
  • FDA
Chemical_Formula
  • C28H40O7
Legacy_Concept_Name
  • Hydrocortisone_Probutate
FULL_SYN
  • Hydrocortisone ProbutatePTNCI
  • HYDROCORTISONE PROBUTATEPTFDAO6550D6K3A
  • PandelBRNCI
DEFINITION
  • The probutate salt form of hydrocortisone, a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2. Lack of phospholipase A2 prevents the release of arachidonic acid, precursor for inflammatory mediator prostaglandins and leukotrienes, from the cell membrane. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production.NCI
code
  • C48023
sameAs
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