About: Hydrocortisone Butyrate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Hydrocortisone Butyrate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Hydrocortisone Butyrate
UMLS_CUI
  • C0352536
CAS_Registry
  • 13609-67-1
FDA_UNII_Code
  • 05RMF7YPWN
Contributing_Source
  • FDA
Chemical_Formula
  • C25H36O6
Legacy_Concept_Name
  • Hydrocortisone_Butyrate
CHEBI_ID
  • CHEBI:31674
FULL_SYN
  • Hydrocortisone ButyratePTNCI
  • HYDROCORTISONE BUTYRATEPTFDA05RMF7YPWN
  • 11-beta,17-alpha,21-Trihydroxy-4-pregnene-3,20-dione 17-alpha-butyrateSNNCI
DEFINITION
  • The butyrate salt form of hydrocortisone, a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2. Lack of phospholipase A2 prevents the release of arachidonic acid, precursor for inflammatory mediator prostaglandins and leukotrienes, from the cell membrane. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leading to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production.NCI
code
  • C48022
sameAs
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