About: Methylprednisolone Acetate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Methylprednisolone Acetate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Methylprednisolone Acetate
NSC_Code
  • 48985
UMLS_CUI
  • C0600901
CAS_Registry
  • 53-36-1
FDA_UNII_Code
  • 43502P7F0P
Contributing_Source
  • FDA
Chemical_Formula
  • C24H32O6
Legacy_Concept_Name
  • Methylprednisolone_Acetate
CHEBI_ID
  • CHEBI:6889
FULL_SYN
  • Depo-MedrolBRNCI
  • Depo-MedrateSYDTPNSC0048985
  • Depo-MedroneSYDTPNSC0048985
  • Methylprednisolone acetateSYDTPNSC0048985
  • D-MedSYDTPNSC0048985
  • Depo-MedrateFBNCI
  • Depo-MedroneFBNCI
  • Methylprednisolone AcetatePTNCI
  • 11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-AcetateSNNCI
  • D-MedFBNCI
  • METHYLPREDNISOLONE ACETATEPTFDA43502P7F0P
DEFINITION
  • The acetate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and antiinflammatory effects. Methylprednisolone acetate is converted into active prednisolone in the body, which activates glucocorticoid receptor mediated gene expression. This includes inducing synthesis of anti-inflammatory protein IkappaB-alpha and inhibiting synthesis of nuclear factor kappaB (NF-kappaB). As a result, proinflammatory cytokine production such as IL-1, IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.NCI
code
  • C48003
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