About: Lidocaine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Lidocaine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Lidocaine Hydrochloride
UMLS_CUI
  • C0546869
CAS_Registry
  • 6108-05-0
FDA_UNII_Code
  • V13007Z41A
Contributing_Source
  • FDA
Chemical_Formula
  • C14H22N2O.HCl.H2O
Legacy_Concept_Name
  • Lidocaine_Hydrochloride
CHEBI_ID
  • CHEBI:60791
FULL_SYN
  • Lidocaine HydrochloridePTNCI
  • LIDOCAINE HYDROCHLORIDEPTFDAV13007Z41A
  • XylotoxSYDTPNSC0040030
  • 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide MonohydrochlorideSNNCI
  • XylotoxFBNCI
  • XylocaineSYDTPNSC0040030
  • XylocitinSYDTPNSC0040030
  • XylocaineBRNCI
  • XylocitinBRNCI
DEFINITION
  • The hydrochloride salt from of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability.NCI
code
  • C48000
sameAs
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