About: Estramustine

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Estramustine Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Estramustine
rdfs:subClassOf	Tubulin Binding Agent Nitrogen Mustard Compounds
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Steroid
Preferred_Name	Estramustine
NSC_Code	89201
UMLS_CUI	C0014921
CAS_Registry	2998-57-4
Accepted_Therapeutic_Use_For	Prostate Neoplasm
In_Clinical_Trial_For	Prostate cancer
FDA_UNII_Code	35LT29625A
Contributing_Source	FDA
ALT_DEFINITION	A combination of the hormone estradiol (an estrogen) and nitrogen mustard (an anticancer drug). Used in the palliative therapy of prostate cancer.NCI-GLOSS
Chemical_Formula	C23H31Cl2NO3
Legacy_Concept_Name	Estramustine
CHEBI_ID	CHEBI:4868
FULL_SYN	ESTRAMUSTINEPTFDA35LT29625A 17beta-(estra-1,3,5(10)-triene-3,17-diol 3-[bis(2-chloroethyl)carbamate]SNNCI EstramustinePTNCI Estradiol 3-[bis(2-chloroethyl)carbamate]SYDTPNSC0089201 estramustinePTNCI-GLOSSCDR0000045195 estradiol 3-bis(2-chloroethyl)carbamateSNNCI Leo 275CNNCI RO 21-8837CNNCI estra-1,3,5(10)triene-317beta-diol 3-[N,N-bis-(2-chloroethyl)carbamate]SNNCI
DEFINITION	A synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. (NCI04)NCI
code	C479
sameAs	ESTRAMUSTINE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0007783
is someValuesFrom of	nodeID://b648969 nodeID://b650325 nodeID://b656928 nodeID://b656987 nodeID://b656991 nodeID://b656994 nodeID://b660121 nodeID://b667073 nodeID://b667110 nodeID://b667113 nodeID://b667116 nodeID://b667119 nodeID://b667121 nodeID://b667127 nodeID://b667367 nodeID://b667371 nodeID://b670958 nodeID://b670962 nodeID://b670964 nodeID://b670967 nodeID://b670969 nodeID://b670972 nodeID://b670976 nodeID://b670977 nodeID://b670981 nodeID://b670983 nodeID://b670986 nodeID://b670988
is sameAs of	ESTRAMUSTINE ESTRAMUSTINE

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 46 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software