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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tolnaftate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tolnaftate
NSC_Code
  • 233648
UMLS_CUI
  • C0040379
CAS_Registry
  • 2398-96-1
FDA_UNII_Code
  • 06KB629TKV
Contributing_Source
  • FDA
Chemical_Formula
  • C19H17NOS
Legacy_Concept_Name
  • Tolnaftate
FULL_SYN
  • Carbanilic Acid, m,N-dimethylthio-, O-2-naphthyl EsterSNNCI
  • NP 27CNNCI
  • AftateBRNCI
  • Carbamothioic Acid, methyl(3-methylphenyl)-, O-2-naphthalenyl EsterSNNCI
  • DesenexBRNCI
  • FocusanSYNCI
  • TOLNAFTATEPTFDA06KB629TKV
  • GenasporBRNCI
  • TinactinSYNCI
  • TolsanilSYNCI
  • AbsorbineBRNCI
  • TolnaftatePTNCI
DEFINITION
  • A thiocarbamate derivative with either fungicidal or fungistatic property. Tolnaftate is a selective, reversible and non-competitive inhibitor of membrane-bound squalene-2,3- epoxidase, an enzyme involved in the biosynthesis of ergosterol. Inhibition leads to the accumulation of squalene and a deficiency in ergosterol, an essential component of fungal cell walls, thereby increasing membrane permeability, disrupting cellular organization and causing cell death. In addition, this agent may also distort the hyphae and stunts mycelial growth in susceptible fungi.NCI
code
  • C47763
sameAs
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