About: Tirofiban Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tirofiban Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tirofiban Hydrochloride
UMLS_CUI
  • C0795668
CAS_Registry
  • 150915-40-5
FDA_UNII_Code
  • 6H925F8O5J
Contributing_Source
  • FDA
Chemical_Formula
  • C22H36N2O5S.HCl.H2O
Legacy_Concept_Name
  • Tirofiban_Hydrochloride
CHEBI_ID
  • CHEBI:9606
FULL_SYN
  • Tirofiban HydrochloridePTNCI
  • Tirofiban Hydrochloride MonohydrateSYNCI
  • TIROFIBAN HYDROCHLORIDEPTFDA6H925F8O5J
  • N-(Butylsulfonyl)-O-(4-(4-piperidinyl)butyl)-L-tyrosine MonohydrochlorideSNNCI
  • MK 383CNNCI
  • AggrastatBRNCI
DEFINITION
  • The hydrochloride salt form of tirofiban, a non-peptide tyrosine derivative with anticoagulant property. Tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. The antagonism prevents adenylyl cyclase activation, which mediated via GP IIb/IIIa receptor complex, and results in decreased levels of cAMP and thereby interferes with platelet membrane function and subsequent platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time.NCI
code
  • C47759
sameAs
http://linked.open...y/mesh/hasConcept
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is sameAs of
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