About: Tacrine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tacrine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tacrine Hydrochloride
NSC_Code
  • 72108
UMLS_CUI
  • C0699954
CAS_Registry
  • 1684-40-8
FDA_UNII_Code
  • 4966RNG0BU
Contributing_Source
  • FDA
Chemical_Formula
  • C13H14N2.HCl
Legacy_Concept_Name
  • Tacrine_Hydrochloride
FULL_SYN
  • TACRINE HYDROCHLORIDEPTFDA4966RNG0BU
  • 1,2,3,4-tetrahydro-9-acridinamine Monohydrochloride MonohydrateSNNCI
  • HydroaminacrineSYNCI
  • CognexBRNCI
  • TenakrinSYNCI
  • Tacrine HydrochloridePTNCI
DEFINITION
  • The hydrochloride salt form of tacrine, an aminoacridine derivative with cognitive stimulating property. Although the mechanism of action has not been fully elucidated, tacrine hydrochloride may bind reversibly to cholinesterase, acetylcholinesterase as well as butyrylcholinesterase, thereby decreasing the breakdown of acetylcholine, and prolonging synaptic actions as well as increased release of acetylcholine. In addition, this agent inhibits monoamine oxidase (MAO) and may inhibit the reuptake of catecholamines and serotonin. Finally, a novel mechanism of action studied in animal models suggests tacrine to attenuate the production of interleukin-1beta in the hippocampus and blood, thereby producing central and peripheral anti-inflammatory effects that may play a role in Alzheimer's disease.NCI
code
  • C47742
http://linked.open...y/mesh/hasConcept
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