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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Sulfinpyrazone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sulfinpyrazone
NSC_Code
  • 75925
UMLS_CUI
  • C0038742
CAS_Registry
  • 57-96-5
FDA_UNII_Code
  • V6OFU47K3W
Contributing_Source
  • FDA
Chemical_Formula
  • C23H20N2O3S
Legacy_Concept_Name
  • Sulfinpyrazone
CHEBI_ID
  • CHEBI:9342
FULL_SYN
  • SULFINPYRAZONEPTFDAV6OFU47K3W
  • 3,5-Pyrazolidinedione, 1,2-diphenyl-4-(2-(phenylsulfinyl)ethyl)-SNNCI
  • SulfinpyrazonePTNCI
  • EnturenSYNCI
  • AnturaneBRNCI
DEFINITION
  • A phenylbutazone derivative with uricosuric and antithrombotic properties. Sulfinpyrazone competitively inhibits reabsorption of urate at the proximal renal tubule in the kidney. This agent acts on the organic anion transport exchanger, thereby increasing uric acid excretion and decreasing serum uric acid levels resulting in the prevention of urate deposition. Sulfinpyrazone also blocks tubular excretion of various acidic drugs, resulting in increased serum concentration of the drugs. In addition, sulfinpyrazone and its active metabolite inhibit the synthesis of thromboxane A2, by competitively inhibiting the activity of cyclooxygenase, thereby preventing platelet aggregation through restoration of platelet survival time to normal, and decreasing platelet adhesiveness to subendothelial cells.NCI
code
  • C47739
sameAs
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