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AttributesValues
rdf:type
rdfs:label
  • Sulfamethizole
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sulfamethizole
UMLS_CUI
  • C0038687
CAS_Registry
  • 144-82-1
FDA_UNII_Code
  • 25W8454H16
Contributing_Source
  • FDA
Chemical_Formula
  • C9H10N4O2S2
Legacy_Concept_Name
  • Sulfamethizole
CHEBI_ID
  • CHEBI:9331
FULL_SYN
  • N(sup 1)-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamideSNNCI
  • SULFAMETHIZOLEPTFDA25W8454H16
  • SulfamethizolePTNCI
  • ProklarBRNCI
  • 2-(p-Aminobenzenesulfonamido)-5-methylthiadiazoleSNNCI
  • 4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamideSNNCI
  • MicrosulBRNCI
  • ThiosulfilBRNCI
DEFINITION
  • A broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial property. Sulfamethizole competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.NCI
code
  • C47736
sameAs
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