About: Sevoflurane     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Sevoflurane
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sevoflurane
UMLS_CUI
  • C0074414
CAS_Registry
  • 28523-86-6
FDA_UNII_Code
  • 38LVP0K73A
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 524061
PDQ_Closed_Trial_Search_ID
  • 524061
Chemical_Formula
  • C4H3F7O
Legacy_Concept_Name
  • Sevoflurane
CHEBI_ID
  • CHEBI:9130
FULL_SYN
  • Ether, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl-SNNCI
  • SevofluranePTNCI
  • 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propaneSNNCI
  • UltaneBRNCI
  • SEVOFLURANEPTFDA38LVP0K73A
DEFINITION
  • A fluorinated isopropyl ether with general anesthetic property. Although the mechanism of action has not been fully elucidated, sevoflurane may act by interfering with the release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alter ionic conductance following receptor activation by a neurotransmitter. Sevoflurane may also interact directly with lipid matrix of neuronal membranes, thereby affecting gating properties of ion channels. In addition, this agent may activate gamma-aminobutyric acid (GABA) receptors hyperpolarizing cell membranes. This results in a general anesthetic effect, a decrease in myocardial contractility and mean arterial pressure as well as an increased respiratory rate.NCI
code
  • C47717
sameAs
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