About: Selegiline Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Selegiline Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Selegiline Hydrochloride
UMLS_CUI
  • C0700467
CAS_Registry
  • 14611-52-0
FDA_UNII_Code
  • 6W731X367Q
Contributing_Source
  • FDA
Chemical_Formula
  • C13H17N.HCl
Legacy_Concept_Name
  • Selegiline_Hydrochloride
CHEBI_ID
  • CHEBI:9087
FULL_SYN
  • L-deprenyl HydrochlorideSYNCI
  • Selegiline HydrochloridePTNCI
  • SELEGILINE HYDROCHLORIDEPTFDA6W731X367Q
  • EmsamBRNCI
  • EldeprylBRNCI
  • Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-, Hydrochloride,(R)-SNNCI
DEFINITION
  • The hydrochloride salt form of selegiline, a levorotatory acetylenic derivative of phenethylamine with antiparkinsonian effect. As a selective monoamine oxidase (MAO) inhibitor, selegiline has the greatest affinity for type B MAO, found mainly in the brain. Selegiline is converted by MAO B to an active moiety, which binds irreversibly at the active site of the enzyme's cofactor FAD (flavin adenine dinucleotide) molecule. This prevents the oxidative deamination of catecholamines and serotonin by MAO B, and leads to an increase in these neurotransmitters' activities resulting in improved motor function. In addition, this agent may inhibit re-uptake of dopamine by the neuron and prolong dopamine activity.NCI
code
  • C47714
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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