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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Prednicarbate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Prednicarbate
UMLS_CUI
  • C0071836
CAS_Registry
  • 73771-04-7
FDA_UNII_Code
  • V901LV1K7D
Contributing_Source
  • FDA
Chemical_Formula
  • C27H36O8
Legacy_Concept_Name
  • Prednicarbate
FULL_SYN
  • PREDNICARBATEPTFDAV901LV1K7D
  • PrednicarbatePTNCI
  • Pregna-1,4-diene-3,20-dione, 17-((ethoxycarbonyl)oxy)-11-hydroxy-21-(1-oxopropoxy)-,(11beta)-SNNCI
  • DermatopBRNCI
DEFINITION
  • A synthetic non-halogenated double-ester derivative of the corticosteroid prednisolone with anti-inflammatory, antipruritic and vasoconstrictive properties. Following skin permeation, prednicarbate enters cells and binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of pro-inflammatory cytokine production by increasing the expression of lipocortins. These block phospholipase A-dependent release of arachidonic acid thereby inhibiting prostaglandin synthesis. This agent also decreases the number of circulating lymphocytes by suppression of the production of vasodilators such as prostacyclin and nitric oxide.NCI
code
  • C47684
sameAs
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