About: Phenyltoloxamine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Phenyltoloxamine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Phenyltoloxamine
UMLS_CUI
  • C0070709
CAS_Registry
  • 92-12-6
FDA_UNII_Code
  • K65LB6598J
Contributing_Source
  • FDA
Chemical_Formula
  • C17H21NO
Legacy_Concept_Name
  • Phenyltoloxamine
FULL_SYN
  • PHENYLTOLOXAMINEPTFDAK65LB6598J
  • PhenyltoloxaminePTNCI
  • AntinSYNCI
  • N,N-Dimethyl-2-(2-(phenylmethyl)phenoxy)ethanamineSNNCI
  • N,N-Dimethyl-2-(alpha-phenyl-o-tolyloxy)ethylamineSNNCI
  • BristaminSYNCI
  • HistionexSYNCI
DEFINITION
  • An ethanolamine derivative with antihistaminic property. Phenyltoloxamine blocks H1 histamine receptors, thereby inhibiting phospholipase A2 and production of endothelium-derived relaxing factor, nitric oxide. Subsequent lack of activation of guanylyl cyclase through nitric oxide results in decreased cyclic GMP levels, thereby inhibiting smooth muscle constriction of various tissues, decreasing capillary permeability and decreasing other histamine-activated allergic reactions.NCI
code
  • C47669
sameAs
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