About: Pentaerythritol Tetranitrate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Pentaerythritol Tetranitrate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pentaerythritol Tetranitrate
UMLS_CUI
  • C0030858
CAS_Registry
  • 78-11-5
FDA_UNII_Code
  • 10L39TRG1Z
Contributing_Source
  • FDA
Chemical_Formula
  • C5H8N4O12
Legacy_Concept_Name
  • Pentaerythritol_Tetranitrate
CHEBI_ID
  • CHEBI:25879
FULL_SYN
  • 1,3-Dinitrato-2,2-bis(nitratomethyl)propaneSNNCI
  • PENTAERYTHRITOL TETRANITRATEPTFDA10L39TRG1Z
  • Pentaerythritol TetranitratePTNCI
  • VasolatSYNCI
  • PentafinSYNCI
  • PeritrateBRNCI
  • 1,3-Propanediol, 2,2-bis((nitrooxy)methyl)-, Dinitrate(ester)SNNCI
DEFINITION
  • The lipid soluble polyol ester of nitric acid belonging to the family of nitrovasodilators that exhibit vasodilatory property. Pentaerythritol tetranitrate releases free nitric oxide (NO) after denitration reaction, which triggers NO-dependent signaling transduction involving soluble guanylate cyclase (sGC). NO binds reversibly to the ferrous-heme center of sGC, thereby causes conformational change and activates the enzyme. Activation results in increasing cellular levels of cyclic guanosine monophosphate (cGMP) within vascular smooth muscle, which results in vasodilation mediated by cGMP-dependent protein kinases. Furthermore, this agent causes arterial and venous bed dilation in a dose-dependent manner.NCI
code
  • C47660
sameAs
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