About: Paroxetine Mesylate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Paroxetine Mesylate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Paroxetine Mesylate
UMLS_CUI
  • C1365510
CAS_Registry
  • 217797-14-3
FDA_UNII_Code
  • M711N184JE
Contributing_Source
  • FDA
Chemical_Formula
  • C19H20FNO3.CH4O3S
Legacy_Concept_Name
  • Paroxetine_Mesylate
FULL_SYN
  • (-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine MesylateSNNCI
  • Paroxetine MethanesulfonateSYNCI
  • PexevaBRNCI
  • Paroxetine MesylatePTNCI
  • Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-,(3S,4R)-, MethanesulfonateSNNCI
  • PAROXETINE MESYLATEPTFDAM711N184JE
DEFINITION
  • The mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex, thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, which resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness.NCI
code
  • C47653
sameAs
is Has_Salt_Form of
is sameAs of
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