About: Palonosetron Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Palonosetron Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Palonosetron Hydrochloride
UMLS_CUI
  • C1310734
CAS_Registry
  • 135729-62-3
Accepted_Therapeutic_Use_For
  • prevention of chemotherapy-induced nausea and vomiting
FDA_UNII_Code
  • 23310D4I19
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat nausea and vomiting caused by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 486366
PDQ_Closed_Trial_Search_ID
  • 486366
Chemical_Formula
  • C19H24N2O.HCl
Legacy_Concept_Name
  • Palonosetron_Hydrochloride
FULL_SYN
  • RS 25259-197CNNCI
  • AloxiPTNCI-GLOSSCDR0000584178
  • 1H-Benz(de)isoquinolin-1-one, 2-(3S)-1-azabicyclo(2.2.2)oct-3-yl-2,3,3a,4,5,6-hexahydro-, Monohydrochloride,(3aS)-SNNCI
  • Palonosetron HydrochloridePTNCI
  • palonosetron hydrochloridePTNCI-GLOSSCDR0000476307
  • AloxiBRNCI
  • PALONOSETRON HYDROCHLORIDEPTFDA23310D4I19
DEFINITION
  • The hydrochloride salt of palonosetron, a carbazole derivative and a selective serotonin receptor antagonist with antiemetic activity. Palonosetron competitively blocks the action of serotonin at 5-hydroxytryptamine type 3 (5-HT3) receptors located on vagal afferents in the chemoreceptor trigger zone (CTZ), resulting in suppression of chemotherapy-induced nausea and vomiting. The CTZ is located in the area postrema on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle and outside the blood-brain barrier (BBB).NCI
code
  • C47650
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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