About: Naftifine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Naftifine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Naftifine Hydrochloride
UMLS_CUI
  • C0304594
CAS_Registry
  • 65473-14-5
FDA_UNII_Code
  • 25UR9N9041
Contributing_Source
  • FDA
Chemical_Formula
  • C21H21N.HCl
Legacy_Concept_Name
  • Naftifine_Hydrochloride
FULL_SYN
  • Naftifine HydrochloridePTNCI
  • (E)-N-methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine-hydrochlorideSNNCI
  • NAFTIFINE HYDROCHLORIDEPTFDA25UR9N9041
  • NaftinBRNCI
  • SN 105843CNNCI
DEFINITION
  • The hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its effect is unknown, it appears to selectively inhibit the enzyme squalene 2,3-epoxidase, thereby inhibiting the biosynthesis of sterol. This results in a decreased amount of sterols, especially ergosterol which is the primary fungal membrane sterol, and a corresponding accumulation of squalene in fungal cells. Naftifine hydrochloride can be fungicidal as well as fungistatic to yeasts depending on the concentration and the organisms involved.NCI
code
  • C47628
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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