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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Nabumetone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Nabumetone
UMLS_CUI
  • C0701331
CAS_Registry
  • 42924-53-8
FDA_UNII_Code
  • LW0TIW155Z
Contributing_Source
  • FDA
Chemical_Formula
  • C15H16O2
Legacy_Concept_Name
  • Nabumetone
FULL_SYN
  • NabumetonePTDCP9187
  • 4-(6-Methoxy-2-naphthalenyl)-2-butanoneSNNCI
  • RelafenBRNCI
  • NABUMETONEPTFDALW0TIW155Z
  • NabumetonePTNCI
DEFINITION
  • A naphthylalkanone and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Nabumetone is a prodrug that upon hepatic catalysis converts into the active moiety 6-methoxy-2-naphthylacetic acid (6MNA). 6MNA inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of nabumetone. The formation of thromboxane A2, by thromboxane synthase, is also decreased and results in an inhibition of platelet aggregation.NCI
code
  • C47627
sameAs
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