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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Minoxidil
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Minoxidil
UMLS_CUI
  • C0730881
CAS_Registry
  • 16317-69-4
  • 38304-91-5
FDA_UNII_Code
  • 5965120SH1
Contributing_Source
  • FDA
Chemical_Formula
  • C9H15N5O
Legacy_Concept_Name
  • Minoxidil
CHEBI_ID
  • CHEBI:6942
FULL_SYN
  • MinoxidilPTDCP30293
  • 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamineSNNCI
  • MINOXIDILPTFDA5965120SH1
  • U 10858CNNCI
  • 2,4-Pyrimidinediamine, 6-(1-Piperidinyl)-, 3-OxideSNNCI
  • RogaineBRNCI
  • AlostilSYNCI
  • LonitenSYNCI
  • MinoxidilPTNCI
DEFINITION
  • An orally administered vasodilator with hair growth stimulatory and antihypertensive effects. Minoxidil is converted into its active metabolite minoxidil sulphate by sulphotransferase enzymes. Minoxidil sulphate exerts its antihypertensive effect by opening of plasma membrane adenosine triphosphate (ATP)-sensitive potassium channels (KATP channels), thereby directly and rapidly relaxing arteriolar smooth muscle and subsequent reduction of elevated systolic and diastolic blood pressure by decreasing peripheral vascular resistance. This agent's hair growth stimulatory effect may be mediated through its vasodilatory activity, thereby increasing cutaneous blood flow, or due to its direct stimulatory effect on hair follicle cells and forcing them from their resting phase into their active growth phase.NCI
code
  • C47623
sameAs
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