About: Memantine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Memantine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Memantine Hydrochloride
NSC_Code
  • 102290
UMLS_CUI
  • C0771988
CAS_Registry
  • 41100-52-1
FDA_UNII_Code
  • JY0WD0UA60
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat dementia caused by Alzheimer disease. It is also being studied in the treatment of side effects from whole-brain radiation therapy for cancer and other conditions. Memantine hydrochloride blocks the uptake of calcium by certain brain cells and decreases their activity. It is a type of N-methyl-D-asparatate (NMDA) receptor antagonist.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 579596
PDQ_Closed_Trial_Search_ID
  • 579596
Chemical_Formula
  • C12H21N.HCl
Legacy_Concept_Name
  • Memantine_Hydrochloride
CHEBI_ID
  • CHEBI:64323
FULL_SYN
  • Memantine HydrochloridePTNCI
  • 1-amino-3,5-dimethyladamantane HydrochlorideSNNCI
  • MEMANTINE HYDROCHLORIDEPTFDAJY0WD0UA60
  • EbixiaSYNCI
  • NamendaPTNCI-GLOSSCDR0000599994
  • NamendaBRNCI
  • memantine hydrochloridePTNCI-GLOSSCDR0000599993
DEFINITION
  • The hydrochloride salt of memantine, a low-affinity, voltage-dependent, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Memantine binds to and inhibits cation channels of glutamanergic NMDA receptors located in the central nervous system (CNS), preventing the prolonged influx of calcium ions and the associated neuronal excitotoxicity, and thereby potentially enhancing cognitive function. Memantine is also a 5-hydroxytryptamine type 3 (5HT3) receptor and nicotinic receptor antagonist.NCI
code
  • C47601
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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