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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Isocarboxazid
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Isocarboxazid
NSC_Code
  • 169893
UMLS_CUI
  • C0022154
CAS_Registry
  • 59-63-2
FDA_UNII_Code
  • 34237V843T
Contributing_Source
  • FDA
Chemical_Formula
  • C12H13N3O2
Legacy_Concept_Name
  • Isocarboxazid
FULL_SYN
  • ISOCARBOXAZIDPTFDA34237V843T
  • IsocarboxazidPTNCI
  • 3-Isoxazolecarboxylic Acid, 5-methyl-, 2-(phenylmethyl)hydrazideSNNCI
  • MarplanBRNCI
  • Ro 5-0831CNNCI
DEFINITION
  • A hydralazine and monoamine oxidase (MAO) inhibitor with antidepressant activity. Isocarboxazid blocks the breakdown (oxidative deamination) of biogenic amines by inhibiting MAO, thereby increasing the concentrations of norepinephrine and 5-hydroxytrytamine (5-HT) at central aminergic receptors. These neurotransmitters are involved in sustaining mood and emotions. The down-regulation of central beta-adrenergic and serotonergic receptors by chronic inhibition of MAO may also contribute to the antidepressant effects seen by isocarboxazid. (NCI05)NCI
code
  • C47573
sameAs
http://linked.open...y/mesh/hasConcept
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