About: Halobetasol Propionate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Halobetasol Propionate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Halobetasol Propionate
UMLS_CUI
  • C0098735
CAS_Registry
  • 66852-54-8
FDA_UNII_Code
  • 91A0K1TY3Z
Contributing_Source
  • FDA
Chemical_Formula
  • C25H31ClF2O5
Legacy_Concept_Name
  • Halobetasol_Propionate
FULL_SYN
  • Halobetasol PropionatePTNCI
  • HALOBETASOL PROPIONATEPTFDA91A0K1TY3Z
  • UltravateBRNCI
  • 21-Chloro-6alpha,9-difluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionateSNNCI
DEFINITION
  • The propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activating gene expression of anti-inflammatory proteins mediated via corticosteroid receptor response element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema, and pruritus through its cutaneous effects on vascular dilation and permeability.NCI
code
  • C47553
sameAs
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