About: Fosphenytoin Sodium     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fosphenytoin Sodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Fosphenytoin Sodium
UMLS_CUI
  • C0284906
CAS_Registry
  • 92134-98-0
FDA_UNII_Code
  • 7VLR55452Z
Contributing_Source
  • FDA
Chemical_Formula
  • C16H13N2O6P.2Na
Legacy_Concept_Name
  • Fosphenytoin_Sodium
FULL_SYN
  • CerebyxBRNCI
  • Fosphenytoin SodiumPTNCI
  • 2,4-Imidazolidinedione, 5,5-diphenyl-3-((phosphonooxy)methyl)-, Disodium SaltSNNCI
  • FOSPHENYTOIN SODIUMPTFDA7VLR55452Z
DEFINITION
  • The sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin upon parental administration. Phenytoin exerts its effect most likely through an enhancement of sodium efflux from neurons in the motor cortex. This leads to a suppression of excessive neuronal firing and spread of seizure activity. Other physiologic effects from actions of phenytoin include modulation of the voltage-dependent calcium channels of neurons, inhibition of calcium flux across neuronal membranes and enhancement of sodium-potassium ATPase activity of neurons and glial cells. (NCI05)NCI
code
  • C47543
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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