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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ezetimibe
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ezetimibe
UMLS_CUI
  • C1142985
CAS_Registry
  • 163222-33-1
FDA_UNII_Code
  • EOR26LQQ24
Contributing_Source
  • FDA
Chemical_Formula
  • C24H21F2NO3
Legacy_Concept_Name
  • Ezetimibe
CHEBI_ID
  • CHEBI:49040
FULL_SYN
  • ZetiaBRNCI
  • EZETIMIBEPTFDAEOR26LQQ24
  • EzedocSYNCI
  • 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinoneSNNCI
  • EzetimibePTNCI
DEFINITION
  • An azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with cholesterol transporters at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol and related phytosterols. As a result, ezetimibe causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Overall, the following effects observed are a reduction of hepatic cholesterol stores and a reduction of total cholesterol, LDL cholesterol, and other triglycerides in the blood.NCI
code
  • C47529
sameAs
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