About: Difenoxin Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Difenoxin Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Difenoxin Hydrochloride
UMLS_CUI
  • C0770333
CAS_Registry
  • 35607-36-4
FDA_UNII_Code
  • VQZ63K01IW
Contributing_Source
  • FDA
Chemical_Formula
  • C28H28N2O2.HCl
Legacy_Concept_Name
  • Difenoxin_Hydrochloride
CHEBI_ID
  • CHEBI:59790
FULL_SYN
  • Difenoxin HydrochloridePTNCI
  • 4-Piperidinecarboxylic Acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, MonohydrochlorideSNNCI
  • DIFENOXIN HYDROCHLORIDEPTFDAVQZ63K01IW
  • Isonipecotic Acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, HydrochlorideSNNCI
DEFINITION
  • A phenylpiperidine with antidiarrheal activity and active metabolite of diphenoxylate. Difenoxin is chemically related to the narcotic opioid meperidine. Difenoxin hydrochloride acts primarily on the gastrointestinal wall by binding to opioid receptors on acetylcholine-containing nerves and inhibits the release of acetylcholine from presynaptic nerve terminals. This leads to a reduction in intestinal motility. Difenoxin hydrochloride also mimics the action of endogenous opioid peptides at the CNS opioid receptors, (primarily mu-receptors), thereby inducing CNS effects.NCI
code
  • C47487
sameAs
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