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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Daptomycin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Daptomycin
UMLS_CUI
  • C0057144
CAS_Registry
  • 103060-53-3
FDA_UNII_Code
  • NWQ5N31VKK
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat certain bacterial skin and bloodstream infections in adults. Cubicin is also being studied in the treatment of fever and neutropenia (an abnormal decrease in the number of neutrophils, a type of white blood cell) in patients with cancer. It is a type of antibiotic.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 469015
PDQ_Closed_Trial_Search_ID
  • 469015
Chemical_Formula
  • C72H101N17O26
Legacy_Concept_Name
  • Daptomycin
CHEBI_ID
  • CHEBI:600103
FULL_SYN
  • N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactoneSNNCI
  • daptomycinPTNCI-GLOSSCDR0000471776
  • CubicinPTNCI-GLOSSCDR0000513057
  • CubicinBRNCI
  • LY146032CNNCI
  • DAPTOMYCINPTFDANWQ5N31VKK
  • DaptomycinPTNCI
DEFINITION
  • A semi-synthetic cyclic lipopeptide antibiotic isolated form the bacterium Streptomyces roseosporus with broad-spectrum antibiotic activity against Gram-positive bacteria. Daptomycin has a distinct mechanism of action, in which it binds to bacterial membrane and causes rapid depolarization of the cell membrane due to calcium-dependant potassium efflux; the loss of membrane potential leads to inhibition of DNA, RNA and protein synthesis, resulting in bacterial cell death. This agent does not penetrate the outer membrane of gram-negative bacteria.NCI
code
  • C47470
sameAs
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