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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Cycloserine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cycloserine
NSC_Code
  • 154851
UMLS_CUI
  • C0010590
CAS_Registry
  • 68-41-7
FDA_UNII_Code
  • 95IK5KI84Z
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat tuberculosis. It is also being studied in the treatment of pain and nerve problems (numbness, tingling) caused by chemotherapy and in the treatment of low back pain, autism, certain anxiety disorders, and schizophrenia. D-cycloserine is a type of antibiotic.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 469006
PDQ_Closed_Trial_Search_ID
  • 469006
Chemical_Formula
  • C3H6N2O2
Legacy_Concept_Name
  • Cycloserine
CHEBI_ID
  • CHEBI:40009
FULL_SYN
  • CycloserinePTNCI
  • D-CycloserineSYNCI
  • D-cycloserinePTNCI-GLOSSCDR0000471784
  • (+)-4-Amino-3-isoxazolidinoneSNNCI
  • OxamycinSYNCI
  • 3-Isoxazolidinone, 4-amino-, d-SNNCI
  • CYCLOSERINEPTFDA95IK5KI84Z
  • SeromycinBRNCI
  • TisomycinSYNCI
  • SeromycinPTNCI-GLOSSCDR0000513053
DEFINITION
  • An analogue of the amino acid D-alanine with broad-spectrum antibiotic and glycinergic activities. D-cycloserine interferes with bacterial cell wall synthesis by competitively inhibiting two enzymes, L-alanine racemase and D-alanine:D-alanine ligase, thereby impairing peptidoglycan formation necessary for bacterial cell wall synthesis. This agent may be bactericidal or bacteriostatic, depending on its concentration at the infection site and the susceptibility of the organism. In addition, D-cycloserine is an excitatory amino acid and partial agonist at the glycine binding site of the NMDA receptor in the central nervous system (CNS); binding to the central NMDA receptor may result in amelioration of neuropathic pain.NCI
code
  • C47466
sameAs
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