About: Cinacalcet Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cinacalcet Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cinacalcet Hydrochloride
UMLS_CUI
  • C1260199
CAS_Registry
  • 364782-34-3
FDA_UNII_Code
  • 1K860WSG25
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 662071
PDQ_Closed_Trial_Search_ID
  • 662071
Chemical_Formula
  • C22H22F3N.HCl
Legacy_Concept_Name
  • Cinacalcet_Hydrochloride
CHEBI_ID
  • CHEBI:48391
FULL_SYN
  • Cinacalcet HydrochloridePTNCI
  • 1-Naphthalenemethanamine, a-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-,(aR)-, HydrochlorideSNNCI
  • CINACALCET HYDROCHLORIDEPTFDA1K860WSG25
  • MimparaFBNCI
  • SensiparBRNCI
DEFINITION
  • The orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels. In addition, by reducing PTH levels, cinacalcet may reduce PSA levels; PTH appears to raise PSA levels and may increase prostate cancer cell growth.NCI
code
  • C47450
sameAs
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