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AttributesValues
rdf:type
rdfs:label
  • Aminophylline
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Aminophylline
NSC_Code
  • 7919
UMLS_CUI
  • C0002575
CAS_Registry
  • 317-34-0
FDA_UNII_Code
  • 27Y3KJK423
Contributing_Source
  • FDA
Chemical_Formula
  • 2C7H8N4O2.C2H8N2
Legacy_Concept_Name
  • Aminophylline
FULL_SYN
  • AmmophyllinSYNCI
  • TruphyllineBRNCI
  • AMINOPHYLLINEPTFDA27Y3KJK423
  • PhyllocontinBRNCI
  • AminophyllinePTNCI
  • 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compound with 1,2-Ethanediamine(2:1)SNNCI
  • Theophyline EthylenediamineSYNCI
  • AminophyllinePTDCP06095
DEFINITION
  • A methylxanthine and derivative of theophylline. Aminophylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Aminophylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart.NCI
code
  • C47393
sameAs
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